| Sa., 19.02.2022 | VfB Auerbach - VfB Germania Halberstadt | 2:5 |
| Sa., 19.02.2022 | BSG Chemie Leipzig - Hertha BSC Berlin II | 2:1 |
| So., 20.02.2022 | FSV Union Fürstenwalde - FC Energie Cottbus | 2:2 |
| So., 20.02.2022 | FSV 63 Luckenwalde - SV Lichtenberg 47 | 4:1 |
| So., 20.02.2022 | FSV Optik Rathenow - SV Tasmania Berlin | 2:0 |
| Mi., 09.03.2022 | FC Carl Zeiss Jena - ZFC Meuselwitz | 2:0 |
| Mi., 09.03.2022 | BFC Dynamo - SV Babelsberg 03 | 1:0 |
| Mi., 16.03.2022 | VSG Altglienicke - Chemnitzer FC | 4:1 |
| Mi., 23.03.2022 | Tennis Borussia Berlin - FC Eilenburg | 5:0 |
| Mi., 23.03.2022 | Berliner AK 07 - 1. FC Lok Leipzig | 0:1 |
| Sp. | S-U-N | Tore | Diff. | P | ||||
|---|---|---|---|---|---|---|---|---|
| 1. |  |  | BFC Dynamo | 25 | 18-4-3 | 62:20 | 42 | 58 |
| 2. | |  | 1. FC Lok Leipzig | 25 | 16-5-4 | 55:24 | 31 | 53 |
| 3. | |  | FC Energie Cottbus | 25 | 14-7-4 | 57:22 | 35 | 49 |
| 4. | |  | FC Carl Zeiss Jena | 25 | 14-6-5 | 46:24 | 22 | 48 |
| 5. | |  | Berliner AK 07 | 25 | 15-3-7 | 40:30 | 10 | 48 |
| 6. | |  | Chemnitzer FC | 25 | 12-9-4 | 41:23 | 18 | 45 |
| 7. | |  | SV Babelsberg 03 | 25 | 13-5-7 | 36:26 | 10 | 44 |
| 8. | |  | VSG Altglienicke | 23 | 12-6-5 | 42:28 | 14 | 42 |
| 9. | |  | FSV 63 Luckenwalde | 26 | 11-6-9 | 44:26 | 18 | 39 |
| 10. | |  | BSG Chemie Leipzig | 26 | 11-5-10 | 29:28 | 1 | 38 |
| 11. | |  | Tennis Borussia Berlin | 24 | 10-5-9 | 36:31 | 5 | 35 |
| 12. | |  | Hertha BSC Berlin II | 26 | 9-6-11 | 41:42 | -1 | 33 |
| 13. | |  | SV Lichtenberg 47 | 26 | 7-7-12 | 32:41 | -9 | 28 |
| 14. | |  | ZFC Meuselwitz | 25 | 7-4-14 | 26:39 | -13 | 25 |
| 15. | |  | VfB Germania Halberstadt | 26 | 6-7-13 | 33:49 | -16 | 25 |
| 16. |  |  | FSV Optik Rathenow | 26 | 3-10-13 | 28:51 | -23 | 19 |
| 17. |  |  | FC Eilenburg | 25 | 4-7-14 | 26:56 | -30 | 19 |
| 18. | |  | VfB Auerbach | 25 | 4-5-16 | 26:63 | -37 | 17 |
| 19. | |  | SV Tasmania Berlin | 26 | 3-7-16 | 19:61 | -42 | 16 |
| 20. | |  | FSV Union Fürstenwalde | 25 | 3-6-16 | 35:70 | -35 | 15 |