| Fr., 01.04.2022 | Hertha BSC Berlin II - VfB Auerbach | 3:0 |
| Fr., 01.04.2022 | SV Tasmania Berlin - Berliner AK 07 | 1:3 |
| Fr., 01.04.2022 | SV Babelsberg 03 - FSV Union Fürstenwalde | 1:2 |
| Sa., 02.04.2022 | FSV 63 Luckenwalde - FSV Optik Rathenow | 1:1 |
| Sa., 02.04.2022 | SV Lichtenberg 47 - Tennis Borussia Berlin | 0:0 |
| Sa., 02.04.2022 | ZFC Meuselwitz - VSG Altglienicke | 0:1 |
| Sa., 02.04.2022 | Chemnitzer FC - BFC Dynamo | 1:3 |
| So., 03.04.2022 | BSG Chemie Leipzig - FC Carl Zeiss Jena | 3:2 |
| So., 03.04.2022 | FC Eilenburg - FC Energie Cottbus | 1:1 |
| So., 03.04.2022 | VfB Germania Halberstadt - 1. FC Lok Leipzig | 2:3 |
| Sp. | S-U-N | Tore | Diff. | P | ||||
|---|---|---|---|---|---|---|---|---|
| 1. |  |  | BFC Dynamo | 31 | 22-5-4 | 70:23 | 47 | 71 |
| 2. |  |  | VSG Altglienicke | 31 | 18-7-6 | 61:34 | 27 | 61 |
| 3. |  |  | 1. FC Lok Leipzig | 29 | 18-6-5 | 61:30 | 31 | 60 |
| 4. | |  | FC Carl Zeiss Jena | 31 | 18-6-7 | 54:28 | 26 | 60 |
| 5. | |  | Berliner AK 07 | 31 | 17-4-10 | 45:35 | 10 | 55 |
| 6. | |  | FC Energie Cottbus | 30 | 15-9-6 | 61:29 | 32 | 54 |
| 7. | |  | Chemnitzer FC | 30 | 15-9-6 | 49:31 | 18 | 54 |
| 8. | |  | Tennis Borussia Berlin | 31 | 13-9-9 | 52:39 | 13 | 48 |
| 9. | |  | SV Babelsberg 03 | 31 | 13-8-10 | 39:32 | 7 | 47 |
| 10. | |  | Hertha BSC Berlin II | 31 | 13-6-12 | 51:43 | 8 | 45 |
| 11. | |  | FSV 63 Luckenwalde | 31 | 12-7-12 | 51:40 | 11 | 43 |
| 12. | |  | BSG Chemie Leipzig | 31 | 12-7-12 | 36:37 | -1 | 43 |
| 13. | |  | SV Lichtenberg 47 | 30 | 9-8-13 | 37:45 | -8 | 35 |
| 14. | |  | ZFC Meuselwitz | 31 | 9-6-16 | 31:45 | -14 | 33 |
| 15. | |  | VfB Germania Halberstadt | 31 | 7-8-16 | 38:59 | -21 | 29 |
| 16. | |  | FC Eilenburg | 31 | 6-9-16 | 32:66 | -34 | 27 |
| 17. | |  | FSV Optik Rathenow | 31 | 3-13-15 | 32:59 | -27 | 22 |
| 18. | |  | VfB Auerbach | 30 | 5-7-18 | 38:71 | -33 | 22 |
| 19. | |  | FSV Union Fürstenwalde | 31 | 5-7-19 | 43:80 | -37 | 22 |
| 20. | |  | SV Tasmania Berlin | 31 | 3-7-21 | 25:80 | -55 | 16 |