| Fr., 04.03.2022 | BFC Dynamo - Hertha BSC Berlin II | 1:0 |
| Fr., 04.03.2022 | FC Carl Zeiss Jena - SV Babelsberg 03 | 1:0 |
| Fr., 04.03.2022 | VfB Auerbach - SV Tasmania Berlin | 9:1 |
| Sa., 05.03.2022 | FSV 63 Luckenwalde - BSG Chemie Leipzig | 5:3 |
| Sa., 05.03.2022 | FSV Optik Rathenow - SV Lichtenberg 47 | 2:4 |
| Sa., 05.03.2022 | Tennis Borussia Berlin - ZFC Meuselwitz | 3:3 |
| So., 06.03.2022 | Berliner AK 07 - FC Eilenburg | 1:0 |
| So., 06.03.2022 | VSG Altglienicke - FC Energie Cottbus | 3:0 |
| So., 27.03.2022 | FSV Union Fürstenwalde - VfB Germania Halberstadt | 1:2 |
| Mi., 13.04.2022 | 1. FC Lok Leipzig - Chemnitzer FC | 1:2 |
| Sp. | S-U-N | Tore | Diff. | P | ||||
|---|---|---|---|---|---|---|---|---|
| 1. |  |  | BFC Dynamo | 27 | 19-4-4 | 63:21 | 42 | 61 |
| 2. | |  | 1. FC Lok Leipzig | 25 | 16-5-4 | 55:24 | 31 | 53 |
| 3. | |  | FC Energie Cottbus | 26 | 15-7-4 | 58:22 | 36 | 52 |
| 4. | |  | FC Carl Zeiss Jena | 26 | 15-6-5 | 47:24 | 23 | 51 |
| 5. | |  | Chemnitzer FC | 26 | 13-9-4 | 42:23 | 19 | 48 |
| 6. | |  | Berliner AK 07 | 26 | 15-3-8 | 40:31 | 9 | 48 |
| 7. | |  | VSG Altglienicke | 24 | 13-6-5 | 45:29 | 16 | 45 |
| 8. | |  | SV Babelsberg 03 | 27 | 13-6-8 | 37:28 | 9 | 45 |
| 9. | |  | FSV 63 Luckenwalde | 28 | 12-6-10 | 49:33 | 16 | 42 |
| 10. | |  | Tennis Borussia Berlin | 26 | 11-6-9 | 41:34 | 7 | 39 |
| 11. | |  | BSG Chemie Leipzig | 28 | 11-5-12 | 32:34 | -2 | 38 |
| 12. | |  | Hertha BSC Berlin II | 28 | 10-6-12 | 45:43 | 2 | 36 |
| 13. | |  | SV Lichtenberg 47 | 28 | 9-7-12 | 37:43 | -6 | 34 |
| 14. | |  | ZFC Meuselwitz | 27 | 8-5-14 | 30:42 | -12 | 29 |
| 15. | |  | VfB Germania Halberstadt | 27 | 6-7-14 | 33:51 | -18 | 25 |
| 16. | |  | FC Eilenburg | 26 | 5-7-14 | 29:58 | -29 | 22 |
| 17. | |  | FSV Optik Rathenow | 28 | 3-11-14 | 31:56 | -25 | 20 |
| 18. | |  | VfB Auerbach | 27 | 5-5-17 | 35:65 | -30 | 20 |
| 19. | |  | SV Tasmania Berlin | 27 | 3-7-17 | 20:70 | -50 | 16 |
| 20. | |  | FSV Union Fürstenwalde | 27 | 3-6-18 | 38:76 | -38 | 15 |