| Fr., 04.02.2022 | BFC Dynamo - ZFC Meuselwitz | 3:0 |
| Fr., 04.02.2022 | FSV Optik Rathenow - VfB Germania Halberstadt | 2:2 |
| Fr., 04.02.2022 | FC Carl Zeiss Jena - FC Eilenburg | 3:1 |
| Sa., 05.02.2022 | Berliner AK 07 - Chemnitzer FC | 1:2 |
| Sa., 05.02.2022 | Hertha BSC Berlin II - SV Lichtenberg 47 | 3:1 |
| Sa., 05.02.2022 | VfB Auerbach - FC Energie Cottbus | 0:2 |
| So., 06.02.2022 | BSG Chemie Leipzig - SV Babelsberg 03 | 3:1 |
| So., 06.02.2022 | FSV 63 Luckenwalde - SV Tasmania Berlin | 2:0 |
| Mi., 23.02.2022 | Tennis Borussia Berlin - 1. FC Lok Leipzig | 0:0 |
| Mi., 02.03.2022 | FSV Union Fürstenwalde - VSG Altglienicke | 1:3 |
| Sp. | S-U-N | Tore | Diff. | P | ||||
|---|---|---|---|---|---|---|---|---|
| 1. |  |  | BFC Dynamo | 24 | 17-4-3 | 59:20 | 39 | 55 |
| 2. |  |  | FC Energie Cottbus | 24 | 14-6-4 | 55:20 | 35 | 48 |
| 3. |  |  | 1. FC Lok Leipzig | 22 | 15-3-4 | 48:21 | 27 | 48 |
| 4. | |  | Berliner AK 07 | 24 | 15-3-6 | 39:26 | 13 | 48 |
| 5. | |  | FC Carl Zeiss Jena | 23 | 14-4-5 | 45:23 | 22 | 46 |
| 6. | |  | Chemnitzer FC | 24 | 11-9-4 | 39:23 | 16 | 42 |
| 7. | |  | SV Babelsberg 03 | 24 | 12-5-7 | 34:25 | 9 | 41 |
| 8. | |  | VSG Altglienicke | 21 | 11-5-5 | 37:26 | 11 | 38 |
| 9. | |  | FSV 63 Luckenwalde | 24 | 10-6-8 | 39:23 | 16 | 36 |
| 10. | |  | Tennis Borussia Berlin | 23 | 10-4-9 | 36:31 | 5 | 34 |
| 11. | |  | BSG Chemie Leipzig | 23 | 10-4-9 | 26:25 | 1 | 34 |
| 12. | |  | Hertha BSC Berlin II | 24 | 9-6-9 | 40:38 | 2 | 33 |
| 13. | |  | SV Lichtenberg 47 | 24 | 6-7-11 | 29:36 | -7 | 25 |
| 14. | |  | ZFC Meuselwitz | 23 | 6-3-14 | 22:38 | -16 | 21 |
| 15. | |  | VfB Germania Halberstadt | 24 | 5-6-13 | 28:47 | -19 | 21 |
| 16. | |  | FC Eilenburg | 24 | 4-6-14 | 26:56 | -30 | 18 |
| 17. | |  | SV Tasmania Berlin | 24 | 3-7-14 | 19:56 | -37 | 16 |
| 18. | |  | FSV Optik Rathenow | 23 | 2-9-12 | 24:46 | -22 | 15 |
| 19. | |  | FSV Union Fürstenwalde | 22 | 3-5-14 | 30:59 | -29 | 14 |
| 20. | |  | VfB Auerbach | 22 | 3-4-15 | 21:57 | -36 | 13 |