| Fr., 05.11.2021 | Hertha BSC Berlin II - 1. FC Lok Leipzig | 0:1 |
| Sa., 06.11.2021 | FSV 63 Luckenwalde - Berliner AK 07 | 0:1 |
| Sa., 06.11.2021 | BSG Chemie Leipzig - VSG Altglienicke | 0:1 |
| Sa., 06.11.2021 | Chemnitzer FC - ZFC Meuselwitz | 1:1 |
| So., 07.11.2021 | FSV Optik Rathenow - Tennis Borussia Berlin | 1:3 |
| So., 07.11.2021 | BFC Dynamo - FSV Union Fürstenwalde | 5:2 |
| So., 07.11.2021 | SV Tasmania Berlin - VfB Germania Halberstadt | 0:0 |
| Mi., 24.11.2021 | SV Lichtenberg 47 - FC Energie Cottbus | 0:4 |
| Mi., 24.11.2021 | FC Carl Zeiss Jena - VfB Auerbach | 2:1 |
| Mi., 24.11.2021 | SV Babelsberg 03 - FC Eilenburg | 1:0 |
| Sp. | S-U-N | Tore | Diff. | P | ||||
|---|---|---|---|---|---|---|---|---|
| 1. |  |  | Berliner AK 07 | 17 | 13-2-2 | 32:14 | 18 | 41 |
| 2. | |  | BFC Dynamo | 17 | 12-3-2 | 41:16 | 25 | 39 |
| 3. |  |  | 1. FC Lok Leipzig | 17 | 10-3-4 | 38:16 | 22 | 33 |
| 4. | |  | VSG Altglienicke | 17 | 9-5-3 | 31:18 | 13 | 32 |
| 5. | |  | FC Energie Cottbus | 16 | 9-4-3 | 39:13 | 26 | 31 |
| 6. |  |  | FC Carl Zeiss Jena | 16 | 9-4-3 | 30:13 | 17 | 31 |
| 7. | |  | FSV 63 Luckenwalde | 17 | 8-5-4 | 27:11 | 16 | 29 |
| 8. | |  | SV Babelsberg 03 | 16 | 8-3-5 | 25:19 | 6 | 27 |
| 9. | |  | Chemnitzer FC | 17 | 6-7-4 | 25:19 | 6 | 25 |
| 10. | |  | Tennis Borussia Berlin | 17 | 7-3-7 | 22:25 | -3 | 24 |
| 11. | |  | BSG Chemie Leipzig | 17 | 6-4-7 | 17:20 | -3 | 22 |
| 12. | |  | SV Lichtenberg 47 | 16 | 5-3-8 | 19:23 | -4 | 18 |
| 13. | |  | Hertha BSC Berlin II | 17 | 4-5-8 | 20:28 | -8 | 17 |
| 14. | |  | VfB Germania Halberstadt | 17 | 5-2-10 | 23:35 | -12 | 17 |
| 15. | |  | SV Tasmania Berlin | 17 | 3-7-7 | 16:39 | -23 | 16 |
| 16. | |  | ZFC Meuselwitz | 17 | 4-2-11 | 18:30 | -12 | 14 |
| 17. | |  | FSV Union Fürstenwalde | 17 | 3-3-11 | 26:49 | -23 | 12 |
| 18. | |  | VfB Auerbach | 16 | 3-3-10 | 19:43 | -24 | 12 |
| 19. | |  | FC Eilenburg | 16 | 2-5-9 | 13:34 | -21 | 11 |
| 20. | |  | FSV Optik Rathenow | 17 | 1-7-9 | 17:33 | -16 | 10 |