| Fr., 01.10.2021 | VfB Germania Halberstadt - FC Energie Cottbus | 0:0 |
| Fr., 01.10.2021 | ZFC Meuselwitz - 1. FC Lok Leipzig | 0:4 |
| Fr., 01.10.2021 | BFC Dynamo - FSV Optik Rathenow | 1:1 |
| Fr., 01.10.2021 | SV Babelsberg 03 - Berliner AK 07 | 1:2 |
| Sa., 02.10.2021 | FSV 63 Luckenwalde - FC Carl Zeiss Jena | 0:0 |
| Sa., 02.10.2021 | SV Lichtenberg 47 - FSV Union Fürstenwalde | 3:2 |
| So., 03.10.2021 | Chemnitzer FC - FC Eilenburg | 2:0 |
| So., 03.10.2021 | BSG Chemie Leipzig - VfB Auerbach | 1:1 |
| So., 03.10.2021 | Hertha BSC Berlin II - Tennis Borussia Berlin | 0:1 |
| So., 03.10.2021 | SV Tasmania Berlin - VSG Altglienicke | 1:1 |
| Sp. | S-U-N | Tore | Diff. | P | ||||
|---|---|---|---|---|---|---|---|---|
| 1. |  |  | Berliner AK 07 | 13 | 10-1-2 | 25:12 | 13 | 31 |
| 2. |  |  | BFC Dynamo | 13 | 9-3-1 | 30:12 | 18 | 30 |
| 3. | |  | 1. FC Lok Leipzig | 12 | 8-2-2 | 29:9 | 20 | 26 |
| 4. | |  | FSV 63 Luckenwalde | 13 | 7-5-1 | 24:8 | 16 | 26 |
| 5. | |  | VSG Altglienicke | 12 | 7-4-1 | 25:11 | 14 | 25 |
| 6. |  |  | SV Babelsberg 03 | 13 | 8-1-4 | 23:15 | 8 | 25 |
| 7. | |  | FC Carl Zeiss Jena | 12 | 7-3-2 | 24:10 | 14 | 24 |
| 8. | |  | FC Energie Cottbus | 10 | 5-3-2 | 28:9 | 19 | 18 |
| 9. | |  | Chemnitzer FC | 12 | 4-4-4 | 15:13 | 2 | 16 |
| 10. | |  | VfB Germania Halberstadt | 11 | 5-1-5 | 20:19 | 1 | 16 |
| 11. | |  | BSG Chemie Leipzig | 13 | 4-4-5 | 14:15 | -1 | 16 |
| 12. | |  | Tennis Borussia Berlin | 11 | 4-2-5 | 16:22 | -6 | 14 |
| 13. | |  | Hertha BSC Berlin II | 13 | 3-4-6 | 14:22 | -8 | 13 |
| 14. | |  | SV Lichtenberg 47 | 12 | 3-2-7 | 11:19 | -8 | 11 |
| 15. | |  | SV Tasmania Berlin | 12 | 2-5-5 | 14:30 | -16 | 11 |
| 16. | |  | FSV Optik Rathenow | 13 | 1-6-6 | 11:22 | -11 | 9 |
| 17. | |  | ZFC Meuselwitz | 13 | 3-0-10 | 13:25 | -12 | 9 |
| 18. | |  | FSV Union Fürstenwalde | 13 | 2-3-8 | 20:37 | -17 | 9 |
| 19. | |  | VfB Auerbach | 12 | 2-1-9 | 14:34 | -20 | 7 |
| 20. | |  | FC Eilenburg | 13 | 0-4-9 | 6:32 | -26 | 4 |